Meredith Grey, the daughter of the once-renowned surgeon Ellis Grey, becomes an intern at the Seattle Grace Hospital. She meets fellow interns Cristina Yang, Isobel "Izzie" Stevens, and George O'Malley, who become her closest friends during the intern program. Other characters include Dr. Miranda Bailey, Alex Karev, an intern who is not very popular with the others (especially Izzie), and renowned surgeons Dr. Derek Shepherd and Dr. Preston Burke. The chief of surgery is Richard Webber, who was once more than close friends with Meredith's mother.
