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Paul Walker as Brian O'Conner, a former LAPD cop who became a fugitive after letting Dominic Toretto escape in the previous film who has now settled in Miami.
Tyrese Gibson as Roman "Rome" Pearce, Brian's childhood friend who is on house arrest after serving time in prison for which he still blames Brian.
Eva Mendes as Monica Fuentes, a U.S. Customs agent working undercover as Carter Verone's aide.
Cole Hauser as Carter Verone, a ruthless Argentinan drug lord whose organization the Custom Service sent Monica and later Brian and Roman to infiltrate.
Ludacris as Tej Parker, an ex-street racer, a race host and a friend of Brian's. He arranges high stakes street racing events in which Brian often races and wins.
Devon Aoki as Suki, a friend of Brian, Tej, and Jimmy. She is the only named female racer in the film, and her crew is made up entirely of women. She drives a hot pink custom Honda S2000.
Drew Sidora as Bootz, a friend of Brian, Tej, and Suki. She is Suki's assistant driver and is also apart of Suki's all girl crew.
James Remar as Agent Markham, a U.S. customs agent in charge of the operation against Verone and Monica's superior.
Thom Barry as Agent Bilkins, who Brian first met during his undercover work in the first movie, who has come to Miami to oversee the situation. As before, he holds a grudging respect for O'Conner's driving and street racing skills.
Jin Auyeung as Jimmy, a mechanic who works for Tej and is a close friend of Brian.
Mark Boone, Jr. as Detective Whitworth, a Miami detective who is forced by Verone to give Pearce and O'Conner a window to deliver his package.
Mo Gallini as Enrique, Verone's bald henchman.
Roberto Sanchez as Roberto, Varone's henchman and Enrique's partner.
Amaury Nolasco as Orange Julius, a street racer who drives an red Mazda RX-7.
Michael Ealy as Slap Jack, a street racer who drives a bronze Toyota Supra.
John Cenatiempo as Korpi, a street racer who drives a 1969 Chevrolet Camaro Yenko S/C.
Eric Etebari as Darden, Korpi's friend who drives a 1970 Dodge Challenger R/T.